Technologies
LIPOMATRIX
102016000059138AN INTELLIGENT MATRIX WITH AN «OILY HEART»
Tablets are the most used, widespread, and practical pharmaceutical form for taking medications and supplements. However, especially in the nutraceutical area, this pharmaceutical form might not be predictable regarding the delivery of the active ingredient; this is due to the lack of testing of specific and reproducible delivery, and to the presence of substances in the formulations that make disintegration difficult (vegetable extracts and metal oxides). Furthermore, in particular for intestinal release (gastroprotective) tablets, there is a lack of highly reproducible tests for gastro-resistance that are also simultaneously appropriate for the conveyed active ingredients (e.g., hydrophilic active ingredients).
THE NECESSITY OF A TECHNOLOGICAL MATRIX THAT IS ABLE TO SIMULTANEOUSLY GUARANTEE GASTRO-RESISTANCE AND PROMPT DISSOLUTION – DISPERSION OF THE ACTIVE INGREDIENT IN THE INTESTINE
OUR SOLUTION IS
LIPOMATRIX
A PATENTED TECHNOLOGICAL SOLUTION BASED ON A MATRIX OF LOW-MELTING LIPIDS AND SELF-EMULSIFIERS THAT ARE NATURALLY GASTRO-RESISTANT
THE TECHNOLOGY BEHIND LIPOMATRIX
IT IS OUR INTESTINE THAT ACTIVATES THE MATRIX ONLY WHERE IT IS NEEDED!
The lipids that make up LIPOMATRIX are not sensitive to acid pH and remain totally neutral in contact with gastric HCl. The matrix has been shown to maintain its form and to not lose its contents for 2 hours in an acid environment of HCl (pH=1.5) at 37°C. The matrix, once made, has no need of film coating to supply gastro-resistance: it is already gastro-resistant.

PHARMACEUTICAL FORM
GASTRO-RESISTANT TABLET
GASTRO-RESISTANT POWDER
Thanks to these pharmaceutical forms, Lipomatrix is able to pass through the stomach and reach the intestine.


EXPERIMENTAL DATA
To verify the behavior of LIPOMATRIX in a gastric environment, 200-mg tablets of boswellic acid were immersed in a SGF (Simulated Gastric Fluid) and a chromatic lipophilic tracer (cupric chlorophyll).

Gastric liquid containing 2 autoemulsifying tablets with 200 mg of boswellic acid each, after 2 hours of magnetic stirring at 37°C. The liquid was completely transparent and colorless (no migration of chlorophyll in the liquid, an index of the lack of disaggregation).

Intact tablets after 120 minutes in simulated gastric fluid.

Enteric liquid containing 2 autoemulsifying tablets with 200 mg of boswellic acid each, after 1/2 hour of magnetic stirring at 37°C. The complete and uniform diffusion of the colored lipophilic tracer (cupric chlorophyll) is evident, demonstrating the complete hydro-dispersion of the lipid matrix.