NANOEMULSION DELIVERY SYSTEM (NeDS)PCT IB2009/055754 (US PATENT ISSUED)
THE MAJOR CHALLENGE IN DEVELOPING A PRODUCT:
ACTIVE INGREDIENTS SOLUBILITY
Most of vegetal or synthetic small molecules are characterized by a high hydrophobicity, which causes poor affinity for biological membranes and insufficient bioavailability. When molecules are not able to solubilize, they are not absorbed by the systemic circulation and do not exert their activity.
OUR SOLUTION IS
A PATENTED TECHNOLOGICAL SYSTEM CONSTITUTED BY A PARTICULAR POLL OF EXCIPIENTS THAT HAS BEEN STUDIED TO:
THE TECHNOLOGY BEHIND NeDS
Nanoemulsions are molecular colloidal dispersions, which have an average diameter between 50 and 300 nm. In particular, Labomar nanoemulsions have an average diameter ranging from 100 to 300 nm.
SUBLINGUAL ORAL SPRAY
Thanks to this kind pf pharmaceutical form, the effect of the first passage through the liver is bypassed due to the faster and more complete absorption guaranteed by the widely-vascularized sublingual mucosa.
VITAMIN D3 ABSORPTION BY INTRAORAL (SPRAY) AND PERORAL (CAPSULES) DELIVERY IN HEALTHY SUBJECTS IN PATIENTS WITH MALABSORPTION SYNDROMES
BIOAVAILABILITY OF A NEW ORAL MELATONIN EMULSION SPRAY COMPARED WITH A STANDARD ORAL FORMULATION ON HEALTHY VOLUNTEERS