Tecnologie
SELF EMULSIFYING ANHYDROUS DISPERSION SYSTEM (SeADS)
PCT IT2009/000373 (PATENT ISSUED)THE MAJOR CHALLENGE IN DEVELOPING A PRODUCT:
ACTIVE INGREDIENTS SOLUBILITY
It often happens that the substances delivered in a product are not very stable in water, for example when live probiotic microorganisms should be delivered in a liquid dosage form, which is notoriously the most difficult in terms of probiotics survival.
OUR SOLUTION IS
A LIQUID OILY DISPERSION OF PROBIOTICS SUITABLE FOR
DELIVERING A GOOD QUANTITY
OF LIVE CELLS
(UP TO 1 BLN CFU
PER DROP)
CREATING A COMPLETELY ANHYDROUS SYSTEM, WHICH IS SUITABLE FOR THE SURVIVAL OF MICROORGANISMS
CREATING A STABLE AND
READY-MADE PRODUCT
WITHOUT ADDING FURTHER
EXCIPIENTS
DELIVERABLE ACTIVE INGREDIENTS
Lactobacillus rhamnosus
Lactobacillus reuterii
LIVE PROBIOTICS
PHARMACEUTICAL FORM
OILY LIQUID DROPS

THANKS TO THIS PHARMACEUTICAL FORM IT IS POSSIBLE TO:
Disperse and deliver live probiotic cells
Increase their survival in the gastric environment
Easily administer the product also to children
Mix the product with water to improve its palatability
STABILITY TESTS
STABILITY OF PROBIOTICS DELIVERED WITH SeADS
Lactobacillus GG – storage conditions 25°C / 60% RH
LONG TERM STABILITY STUDY DATA
Packaging: Glass vial vith dropper | Storage conditions: 25 °C / 60 % RH Sampling: Initial (0), 2, 3, 6, 12, 18 |
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TEST | REQUIREMENTS | INITIAL | 2 MONTHS | 3 MONTHS | 6 MONTHS | 12 MONTHS | 18 MONTHS |
ORGANOLEPTIC | Yellowish viscous dispersion of lactic acid bacteria in oil |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
PROBIOTICS | ≥ 1 bn UFC/gtt | 1,2 bn UFC/gtt | 1,2 bn UFC/gtt | 1,6 bn UFC/gtt | 1,4 bn UFC/gtt | 1,5 bn UFC/gtt | 1,1 bn UFC/gtt |
ACIDITY (% OLEIC ACID) |
≥ 5% | 0,27 | 0,23 | 0,21 | 0,16 | 0,25 | 0,26 |
PROXIDES (MEQ 0² / KG) |
< 10 meq 0² / Kg | < 0,25 | < 0,25 | < 0,25 | < 0,25 | < 0,25 | < 0,25 |
STABILITY OF PROBIOTICS DELIVERED WITH SeADS
Lactobacillus GG – storage conditions 4°C / No humidity
Packaging: Glass vial vith dropper | Storage conditions: 4 °C / no humidity Sampling: Initial (0), 3, 6, 12, 18 |
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TEST | REQUIREMENTS | INITIAL | 3 MONTHS | 6 MONTHS | 12 MONTHS | 18 MONTHS |
ORGANOLEPTIC | Yellowish viscous dispersion of lactic acid bacteria in oil |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
Compliant to requirements |
PROBIOTICS | ≥ 1 bn UFC/gtt | 1,2 bn UFC/gtt | 1,6 bn UFC/gtt | 1,5 bn UFC/gtt | 1,5 bn UFC/gtt | 1,6 bn UFC/gtt |